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Arsenal could have three derby debutants in action on Saturday - Calum Chambers, Danny Welbeck and Alexis Sanchez. All three are in fine fettle.
Wenger praised Chambers again ahead of this weekend's game after the 19-year-old handled his midweek Southampton reunion with his now customary calmness. Welbeck broke his duck in his last appearance and is gradually finding the rhythm of Arsenal's game. As for Alexis, he looks more and more like Arsenal's trump card. Their game-changer. The club's marquee summer signing scores vital goals - the winner against Besiktas - and spectacular ones - see Manchester City at home.
Tuesday night's unstoppable free-kick, albeit in a losing cause, showcased Alexis' ability to make the difference and Wenger thinks he will get better and better.
"His free-kick was fantastic and he will be of course an important asset offensively once he has adapted to our game," said the manager.
"I still think he's in an adaptation period at the moment but once he has adapted to the way we want to play he will be a fantastic asset for us."
With Theo Walcott not due back until after the international break, Alexis could start on the right against Tottenham. Mathieu Flamini is also in contention after shrugging off a leg problem, but Nacho Monreal (back) is not ready to return.
Tottenham made a raft of new signings last year but this summer their most significant addition was new manager Mauricio Pochettino.
Before he joined Southampton, the Argentine was best known to English football fans as the man who brought down Michael Owen to concede a penalty in the 1998 World Cup.
Pochettino punched well above his weight on the south coast and Tottenham believe he is the man to get the most out of an expensively-assembled squad at White Hart Lane.
The Spurs manager is a former team-mate of Arsenal captain Mikel Arteta at Paris Saint-Germain and Wenger is a fan.
"It was not easy for him [at Southampton] because [Nigel] Adkins had done a great job," said the Frenchman. "He came on and he did a great job as well.
"Now he's at Spurs and it's another level, another demand and the expectation level is higher. It's a new experience for him but he's shown at Southampton that he can cope with the pressure."
Tottenham have made additions to their playing squad - Ben Davies, Eric Dier and Federico Fazio among them - but Pochettino's main concern will be to coax the best out of the likes of Erik Lamela, who struggled to impose himself in his first season in the Premier League.