Manchester United manager David Moyes says Wayne Rooney, who missed Wednesday's win over Stoke with a groin injury, has "a chance" of being fit.
Nani has been ruled out for "a few weeks" with a hamstring injury, but Nemanja Vidic is ready to return after missing the last two games with a minor injury.
West Ham will again be without Kevin Nolan, with the midfielder serving the last of a three-match suspension following his red card against Liverpool. Ravel Morrison returned to the side last week following his suspension, and is expected to maintain his role as the attacking midfielder against United.
James Tomkins is back in the squad after failing a fitness test on a groin injury in midweek.