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St. Mary's Stadium
Pablo Daniel Osvaldo, who signed from Roma on Sunday, is in line to make his debut against Paolo Di Canio's side but it will not be from the start, with Mauricio Pochettino cautious of throwing his star man in at the deep end. Teenage defender Calum Chambers could retain his place with Nathaniel Clyne short of fitness following a pre-season injury.
Craig Gardner and David Vaughan both return from suspension, though the former may struggle to oust Ondrej Celustka from the right-back berth. Kieran Westwood looks to be ahead of Vito Mannone as Paolo Di Canio’s first-choice stopper, while Valentin Roberge is set to partner John O’Shea in defence, with Wes Brom still sidelined with a knee complaint.