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Moyes has problems in attack for with Wayne Rooney suspended following his fifth booking of the season in the defeat by Everton. And with Robin van Persie still sidelined due to the toe and groin problems which have kept him out since scoring the winner against Arsenal, the onus will be on Javier Hernandez and Danny Welbeck in attack.
Phil Jones is available again after missing the Everton game through suspension, while Moyes is expected to shake up his midfield after Marouane Fellaini and Ryan Giggs started in the centre in midweek.
Alan Pardew has stuck largely to the same team in recent weeks as his side have climbed the table into the European places, but after a 3-0 midweek loss at Swansea he could freshen up his side with a couple of changes.
Papiss Cisse and Hatem Ben Arfa should have recovered from the respective heel injury and illness which kept them out on Wednesday.